E-book Particulars :
Language English
Pages 664
Format PDF
Dimension 29.5 MB

 

Medicinal Chemistry A Molecular and Biochemical Approach Third Version by Thomas Nogrady


 

There have been many adjustments in medicinal chemistry and molecular pharmacology for the reason that second version of this e-book was revealed in 1988. Accordingly, it has required intensive updating. This course of was initiated within the Chemistry Division of Queen’s College, Kingston, Canada the place Dr. Nico van Gelder, an Adjunct Emeritus Professor, launched the now retired Thomas Nogrady to Donald Weaver, a medicinal chemist and medical neurologist. Collectively, Weaver and Nogrady undertook the problem of updating this e-book. On this approach the third version of Medicinal Chemistry was began and the 2 authors have labored collectively to make sure a continuity within the type and content material that has made this e-book well-liked amongst college students and researchers alike.

The areas of change on this new version are many and assorted. Since molecular modeling has assumed an more and more outstanding function in drug discovery, we’ve got expanded the dialogue of modeling strategies. Description of different new strategies corresponding to excessive throughput screening and purposes of genomics in drug design have additionally been added. By way of medicinal chemistry purposes, neuropharmacology has loved many advances previously decade; a lot new info from this area has been included.

 

In live performance with these advances, new therapies have been launched for Alzheimer’s illness, Parkinson’s illness, a number of sclerosis and epilepsy – these new therapies are explicitly mentioned within the third version. Rising problems like these of protein folding (e.g. Creutzfeldt-Jakob illness and different prion problems) are additionally thought of. Chapter 5 on hormonal therapies has been totally up to date and re-organized. A whole new chapter on the immune system has been added (chapter 6), reflecting the elevated curiosity in therapeutic molecular manipulation of immunity. Rising enzyme targets in drug design (e.g. kinases, caspases) are discusses on this version.

Latest info on voltage-gated and ligand-gated ion channels has additionally been integrated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anti-cancer brokers, in addition to therapies for hyperlipidemia and for peptic ulcer, have been considerably expanded. Regardless of these many adjustments, the general construction and philosophy of the e-book stay unchaged. Therapeutic brokers are organized in response to their targets – the conceptual centerpiece of the primary two editions. The 9 chapters of the third version are grouped in two components:

 

the essential ideas of medicinal chemistry (chapters 1–3), and purposes of medicinal chemistry from a target-centered viewpoint (chapters 4–9). Given this organizational construction, the e-book is just not a listing of medication. It doesn’t current medicinal chemistry in a “phone listing of medication” approach. Quite, it emphasizes the understanding of mechanisms of drug motion, which incorporates drug and receptor construction. The e-book’s target-centered philosophy services a transparent, mechanistic understanding of how and why medicine work. This could give college students a conceptual framework that can allow them to proceed studying about medicine and drug motion lengthy after they’ve left college.

As with the primary and second editions, this textual content is aimed primarily at college students of pharmacy, pharmacology and chemistry who’re concerned with drug design and improvement. It gives the core of biochemical- and molecular-level eager about medicine wanted for a fundamental medicinal chemistry course. One other new characteristic of this version is designed to boost the e-book’s attraction to all readers: the a number of sections on the “Medical–Molecular Interface.” These sections strengthen the e-book’s medical relevance by making it simpler to know the remedy of human illness at a molecular degree.

 

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