Molecular Biology in Medicinal Chemistry :: DESCRIPTION : This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

TABLE OF CONTENTS

MOLECULAR TARGETS

Cellular Assays in Drug Discovery

Gene Knockout Models

Reporter Gene Assay Systems for the Investigation of GPCRs

From the Human Genome to New Drugs: The Potential of Orphan GPCRs

SYNTHESIS

Stereoselective Synthesis with the Help of Recombinant Enzymes

Nucleic Acid Drugs

ANALYSIS

Recent Trends in Enantioseparation of Chiral Drugs

Affinity Chromatography

NMR-based Drug Discovery

13C- and 15N-Isotopic Labeling of Proteins

Antibody Fragments as Crystallization Enhancers

KINETICS, METABOLISM AND TOXICOLOGY

Pharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug Response

Pharmacogenomics of Bioavaliability and Elimination

Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology

Molecular Biology in Medicinal Chemistry – D. Steinhilber

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