Applications of Domino Transformations in Organic Synthesis by Scott A. Snyder :: As the pace and breadth of research intensifies, organic synthesis is playing an increasingly central role in the discovery process within all imaginable areas of science: from pharmaceuticals, agrochemicals, and materials science to areas of biology and physics, the most impactful investigations are becoming more and more molecular. As an enabling science, synthetic organic chemistry is uniquely poised to provide access to compounds with exciting and valuable new properties. Organic molecules of extreme complexity can, given expert knowledge, be prepared with exquisite efficiency and selectivity, allowing virtually any phenomenon to be probed at levels never before imagined. With ready access to materials of remarkable structural diversity, critical studies can be conducted that reveal the intimate workings of chemical, biological, or physical processes with stunning detail. The sheer variety of chemical structural space required for these investigations and the design elements necessary to assemble molecular targets of increasing intricacy place extraordinary demands on the individual synthetic methods used. They must be robust and provide reliably high yields on both small and large scales, have broad applicability, and exhibit high selectivity. Increasingly, synthetic approaches to organic molecules must take into account environmental sustainability. Thus, atom economy and the overall environmental impact of the transformations are taking on increased importance.
The need to provide a dependable source of information on evaluated synthetic methods in organic chemistry embracing these characteristics was first acknowledged over 100 years ago, when the highly regarded reference source Houben–Weyl Methoden der Organischen Chemie was first introduced. Recognizing the necessity to provide a modernized, comprehensive, and critical assessment of synthetic organic chemistry, in 2000 Thieme launched Science of Synthesis, Houben–Weyl Methods of Molecular Transformations. This effort, assembled by almost 1000 leading experts from both industry and academia, provides a balanced and critical analysis of the entire literature from the early 1800s until the year of publication. The accompanying online version of Science of Synthesis provides text, structure, substructure, and reaction searching capabilities by a powerful, yet easy-to-use, intuitive interface.
From 2010 onward, Science of Synthesis is being updated quarterly with high-quality content via Science of Synthesis Knowledge Updates. The goal of the Science of Synthesis Knowledge Updates is to provide a continuous review of the field of synthetic organic chemistry, with an eye toward evaluating and analyzing significant new developments in synthetic methods. A list of stringent criteria for inclusion of each synthetic transformation ensures that only the best and most reliable synthetic methods are incorporated. These efforts guarantee that Science of Synthesis will continue to be the most up-to-date electronic database available for the documentation of validated synthetic methods.
Applications of Domino Transformations in Organic Synthesis by Scott A. Snyder
|Title:||Applications of Domino Transformations in Organic Synthesis|
|Editor:||Scott A. Snyder|
Author(s): Scott A. Snyder, Erick M. Carreira, Carl P. Decicco, Alois Fürstner, Guido Koch, Gary A. Molander, Ernst Schaumann
Applications of Domino Transformations in Organic Synthesis, Volume 1
Applications of domino transformations in organic synthesis Volume 2
[PDF] Applications of Domino Transformations in Organic Synthesis by Scott A. Snyder Table Of Contents
Pericyclic reactions —
The Diels-Alder cycloaddition reaction in the context of domino processes —
Domino reactions including [2+2], [3+2], or [5+2] cycloadditions —
Domino transformations involving an electrocyclization reaction —
Sigmatropic shifts and Ene reactions (excluding [3,3]) —
Domino transformations initiated by of proceeding through [3,3]-sigmatropic rearrangements —
Intermolecular alkylative dearomatization of phenolic derivatives in organic synthesis —
Additions to alkenes and C=O and C=N bonds —
Additions to nonactivated C=C bonds. Organocatalyzed addition to activated C=C bonds —
Addition to monofunctional C=O bonds —
Additions to C=N bonds and nitriles