Modern NMR Approaches to the Structure Elucidation of Natural Products 2nd Edition by David Rovnyak

Book Description:

Strychnine’s poisonous nature was known in 16th century Europe, and the alkaloid was isolated in pure form for the first time in 1818. Then began a more than century-long quest to unravel the structure of strychnine that led to two Nobel prizes, clearly without the assistance of the modern spectroscopic methods to which we now have access. In his 1963 report of the synthesis, Woodward said, “The tangled skein of atoms which constitutes its molecule provided a fascinating structural problem that was pursued intensively during the century just past, and was solved finally only within the last decade.” The structure elucidation of complex natural products is facilitated today by access to modern instrumentation and experimental techniques. Using a modern 600 MHz NMR spectrometer equipped with a 1.7 mm cryogenic probe and a 1 mg sample, it is now possible to acquire a comprehensive suite of 2D NMR spectra that rigorously characterizes the complex structure of strychnine in a scant 24 hours. When the 2D NMR data are combined with Computer-Assisted Structure Elucidation methods, the structure can be solved in mere seconds. It is against this historical backdrop that these two volumes regarding the Structure Elucidation of Natural Products by NMR is set.

Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, and carbohydrates. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be scarce as natural product samples.

Title: Modern NMR Approaches to the Structure Elucidation of Natural Products
Editor: Antony J. Williams, Gary E. Martin, David Rovnyak
Edition: 2nd ed.
Publisher: Royal Society of Chemistry
Length: 532 pages
Size: 26.5 MB
Language: English

Modern NMR Approaches to the Structure Elucidation of Natural Products, Volume 2: Data Acquisition and Applications to Compound Classes





Modern NMR Approaches to the Structure Elucidation of Natural Products: Volume 1: Instrumentation and Software

Author(s): Antony Williams, Gary Martin, David Rovnyak (eds.)

Publisher: Royal Society of Chemistry, Year: 2015

ISBN: 184973383X



[PDF] Modern NMR Approaches to the Structure Elucidation of Natural Products by David Rovnyak Table Of Contents

An introduction to Modern NMR Spectroscopy for the Elucidation of Natural Products
NMR Magnets, a Historical Overview
Small volume NMR – Microprobes and Nanoprobes
Cryogenically Cooled NMR Probes: A Revolution for NMR Spectroscopy
Application of LC-NMR to the study of natural products
Application of non-uniform sampling for sensitivity enhancement of small molecule heteronuclear correlation NMR spectra
NMR Spectroscopy using Several Parallel Receivers
Dereplication using H1 NMR
Application of Computer Assisted Structure Elucidation
Multidimensional Spin Correlations by Covariance NMR
Future Approaches For Data Processing
Molecular structure identification by atomic force microscopy


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